Diabetes Control and Complications Trial (DCCT)
The DCCT study was a multicenter trial designed to test the proposition that the complications of diabetes mellitus are related to elevation of the plasma glucose concentration. The clinical study ran during 1983-1993.
- The study showed that keeping blood glucose leves as close to normal as possible slows the onset and progression of eye, kidney and nerve damage caused by diabetes type 1.
United Kingdom Prospecive Diabetes Study (UKPDS)
The UKPDS study was a landmark trial of glycemic therapies in patients with newly diagnosed type 2 diabetes. The study was running during 1977-1991 at 23 clinical sites in the UK.
- Data suggest that any improvement in glycemic control across the diabetic range is likely to reduce the risk of diabetic complications fo type 2 diabetes, previously often considered as inevitable, could be reduced by improving blood glucose and/or blood pressure.
- Lowering HbA1c with 1% NGSP, from 8% to 7%, decreases the deaths related to diabetes (21%), microvascular complications (37%) and myocardial infarction (14%).